Plant Transcription factor database - Universität Potsdam
version: 3.0

Selaginella moellendorffii TRAF Family


Stogios et al. 2005:The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. The BTB domain is typically found as a single copy in proteins that contain only one or two other types of domain, and this defines the BTB-zinc finger (BTB-ZF), BTB-BACK-kelch (BBK), voltage-gated potassium channel T1 (T1-Kv), MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP) families of proteins, among others. BTB-ZF proteins are also known as the POK (POZ and Krüppel zinc finger) proteins. Many members of this large family have been characterized as important transcriptional factors, and several are implicated in development and cancer, most notably BCL6, leukemia/lymphoma related factor (LRF)/Pokemon, PLZF, hypermethylated in cancer (HIC)1 and Myc interacting zinc finger (MIZ)1.

Members of this family
  SHOULD possess BTB domain
  SHOULD NOT possess BACK MATH NPH3 zf-TAZ domains

Domain alignments

This family is also present in:


There are 12 gene models in this family

Gene modelDescriptionDomains
107813 e_gw1.35.138.1 Ank BTB
164824 estExt_Genewise1Plus.C_10724 Arm BTB
422152 fgenesh2_pg.C_scaffold_55000062 BTB TPR_1
438494 estExt_fgenesh2_pg.C_30348 BTB
440857 estExt_fgenesh2_pg.C_120387 Ank BTB
58268 gw1.30.480.1 BTB
74877 e_gw1.0.2218.1 Ank BTB
78850 e_gw1.2.1406.1 BTB
82941 e_gw1.5.981.1 BTB
88313 e_gw1.9.344.1 Ank BTB
89237 e_gw1.10.44.1 BTB
92030 e_gw1.12.213.1 BTB

General references

Deweindt, C; Albagli, O; Bernardin, F; Dhordain, P; Quief, S; Lantoine, D; Kerckaert, JP; Leprince, D. 1995. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6(12):1495-503 PUBMEDID:9019154
Stogios, PJ; Downs, GS; Jauhal, JJ; Nandra, SK; Privé, GG. 2005. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6(10):R82 PUBMEDID:16207353