Plant Transcription factor database - Universität Potsdam
version: 3.0

Arabidopsis thaliana TUB Family

Description

Lai et al. 2004: In mammals, TUBBY-like proteins play an important role in maintenance and function of neuronal cells during postdifferentiation and development. We have identified a TUBBY-like protein gene family with 11 members in Arabidopsis, named AtTLP1-11. Although seven of the AtTLP genes are located on chromosome I, no local tandem repeats or gene clusters are identified. Except for AtTLP4, reverse transcription-PCR analysis indicates that all these genes are expressed in various organs in 6-week-old Arabidopsis. AtTLP1, 2, 3, 6, 7, 9, 10, and 11 are expressed ubiquitously in all the organs tested, but the expression of AtTLP5 and 8 shows dramatic organ specificity. These 11 family members share 30% to 80% amino acid similarities across their conserved C-terminal tubby domains. Unlike the highly diverse N-terminal region of animal TUBBY-like proteins, all AtTLP members except AtTLP8 contain a conserved F-box domain (51-57 residues). The interaction between AtTLP9 and ASK1 (Arabidopsis Skp1-like 1) is confirmed via yeast (Saccharomyces cerevisiae) two-hybrid assays. Abscisic acid (ABA)-insensitive phenotypes are observed for two independent AtTLP9 mutant lines, whereas transgenic plants overexpressing AtTLP9 are hypersensitive to ABA. These results suggest that AtTLP9 may participate in the ABA signaling pathway.

Members of this family
  SHOULD possess Tub domain

Domain alignments

This family is also present in:

References

There are 16 gene models in this family



Gene modelDescriptionDomains
AT1G16070.1 AtTLP8 (TUBBY LIKE PROTEIN 8); transcription factor Tub
AT1G16070.2 AtTLP8 (TUBBY LIKE PROTEIN 8) Tub
AT1G25280.1 AtTLP10 (TUBBY LIKE PROTEIN 10); phosphoric diester hydrolase/ transcription factor F-box Tub
AT1G25280.2 AtTLP10 (TUBBY LIKE PROTEIN 10); phosphoric diester hydrolase/ transcription factor Tub
AT1G25280.3 AtTLP10 (TUBBY LIKE PROTEIN 10) Tub
AT1G43640.1 AtTLP5 (TUBBY LIKE PROTEIN 5); phosphoric diester hydrolase/ transcription factor F-box Tub
AT1G47270.1 AtTLP6 (TUBBY LIKE PROTEIN 6); phosphoric diester hydrolase/ transcription factor F-box Tub
AT1G53320.1 AtTLP7 (TUBBY LIKE PROTEIN 7); phosphoric diester hydrolase/ transcription factor F-box Tub
AT1G76900.1 AtTLP1 (TUBBY LIKE PROTEIN 1); phosphoric diester hydrolase/ transcription factor F-box Tub
AT1G76900.2 AtTLP1 (TUBBY LIKE PROTEIN 1); phosphoric diester hydrolase/ transcription factor F-box Tub
AT2G18280.1 AtTLP2 (TUBBY LIKE PROTEIN 2); phosphoric diester hydrolase/ transcription factor F-box Tub
AT2G18280.2 AtTLP2 (TUBBY LIKE PROTEIN 2); phosphoric diester hydrolase/ transcription factor F-box Tub
AT2G47900.1 AtTLP3 (TUBBY LIKE PROTEIN 3); phosphoric diester hydrolase/ transcription factor F-box Tub
AT2G47900.2 AtTLP3 (TUBBY LIKE PROTEIN 3); phosphoric diester hydrolase/ transcription factor F-box Tub
AT3G06380.1 ATTLP9 (TUBBY-LIKE PROTEIN 9); phosphoric diester hydrolase/ protein binding / transcription factor F-box Tub
AT5G18680.1 AtTLP11 (TUBBY LIKE PROTEIN 11); phosphoric diester hydrolase/ transcription factor F-box Tub

General references

Boggon, TJ; Shan, WS; Santagata, S; Myers, SC; Shapiro, L. 1999. Implication of tubby proteins as transcription factors by structure-based functional analysis. Science 286(5447):2119-25 PUBMEDID:10591637
Lai, CP; Lee, CL; Chen, PH; Wu, SH; Yang, CC; Shaw, JF. 2004. Molecular analyses of the Arabidopsis TUBBY-like protein gene family. Plant Physiol. 134(4):1586-97 PUBMEDID:15064372
Santagata, S; Boggon, TJ; Baird, CL; Gomez, CA; Zhao, J; Shan, WS; Myszka, DG; Shapiro, L. 2001. G-protein signaling through tubby proteins. Science 292(5524):2041-50 PUBMEDID:11375483