Plant Transcription factor database - Universität Potsdam
version: 3.0

Oryza sativa subsp. indica TUB Family


Lai et al. 2004: In mammals, TUBBY-like proteins play an important role in maintenance and function of neuronal cells during postdifferentiation and development. We have identified a TUBBY-like protein gene family with 11 members in Arabidopsis, named AtTLP1-11. Although seven of the AtTLP genes are located on chromosome I, no local tandem repeats or gene clusters are identified. Except for AtTLP4, reverse transcription-PCR analysis indicates that all these genes are expressed in various organs in 6-week-old Arabidopsis. AtTLP1, 2, 3, 6, 7, 9, 10, and 11 are expressed ubiquitously in all the organs tested, but the expression of AtTLP5 and 8 shows dramatic organ specificity. These 11 family members share 30% to 80% amino acid similarities across their conserved C-terminal tubby domains. Unlike the highly diverse N-terminal region of animal TUBBY-like proteins, all AtTLP members except AtTLP8 contain a conserved F-box domain (51-57 residues). The interaction between AtTLP9 and ASK1 (Arabidopsis Skp1-like 1) is confirmed via yeast (Saccharomyces cerevisiae) two-hybrid assays. Abscisic acid (ABA)-insensitive phenotypes are observed for two independent AtTLP9 mutant lines, whereas transgenic plants overexpressing AtTLP9 are hypersensitive to ABA. These results suggest that AtTLP9 may participate in the ABA signaling pathway.

Members of this family
  SHOULD possess Tub domain

Domain alignments

This family is also present in:


There are 13 gene models in this family

Gene modelDescriptionDomains
OsIBCD002885 Chr01_4543,1071,,,1,1071, F-box Tub
OsIBCD003367 Chr01_5226,981,,,1,981, F-box Tub
OsIBCD003982 Chr01_6154,1335,,,1,1335, F-box Tub
OsIBCD007700 Chr02_4749,1287,,,1,1287, F-box Tub
OsIBCD010154 Chr03_2257,1212,,,1,1212, F-box Tub
OsIBCD016083 Chr04_5268,1305,,,1,1305, F-box Tub
OsIBCD018149 Chr05_3406,1338,,,1,1338, F-box Tub
OsIBCD018594 Chr05_4090,1110,,,1,1110, F-box Tub
OsIBCD018867 Chr05_4470,1059,,,1,1059, F-box Tub
OsIBCD024524 Chr07_4018,1221,,,1,1221, F-box Tub
OsIBCD024732 Chr08_31,1341,,,1,1341, F-box Tub
OsIBCD031930 Chr11_516,1290,,,1,1290, F-box Tub
OsIBCD034132 Chr12_593,1338,,,1,1338, F-box Tub

General references

Boggon, TJ; Shan, WS; Santagata, S; Myers, SC; Shapiro, L. 1999. Implication of tubby proteins as transcription factors by structure-based functional analysis. Science 286(5447):2119-25 PUBMEDID:10591637
Lai, CP; Lee, CL; Chen, PH; Wu, SH; Yang, CC; Shaw, JF. 2004. Molecular analyses of the Arabidopsis TUBBY-like protein gene family. Plant Physiol. 134(4):1586-97 PUBMEDID:15064372
Santagata, S; Boggon, TJ; Baird, CL; Gomez, CA; Zhao, J; Shan, WS; Myszka, DG; Shapiro, L. 2001. G-protein signaling through tubby proteins. Science 292(5524):2041-50 PUBMEDID:11375483