Plant Transcription factor database - Universität Potsdam
version: 3.0

Oryza sativa subsp. japonica TUB Family

Description

Lai et al. 2004: In mammals, TUBBY-like proteins play an important role in maintenance and function of neuronal cells during postdifferentiation and development. We have identified a TUBBY-like protein gene family with 11 members in Arabidopsis, named AtTLP1-11. Although seven of the AtTLP genes are located on chromosome I, no local tandem repeats or gene clusters are identified. Except for AtTLP4, reverse transcription-PCR analysis indicates that all these genes are expressed in various organs in 6-week-old Arabidopsis. AtTLP1, 2, 3, 6, 7, 9, 10, and 11 are expressed ubiquitously in all the organs tested, but the expression of AtTLP5 and 8 shows dramatic organ specificity. These 11 family members share 30% to 80% amino acid similarities across their conserved C-terminal tubby domains. Unlike the highly diverse N-terminal region of animal TUBBY-like proteins, all AtTLP members except AtTLP8 contain a conserved F-box domain (51-57 residues). The interaction between AtTLP9 and ASK1 (Arabidopsis Skp1-like 1) is confirmed via yeast (Saccharomyces cerevisiae) two-hybrid assays. Abscisic acid (ABA)-insensitive phenotypes are observed for two independent AtTLP9 mutant lines, whereas transgenic plants overexpressing AtTLP9 are hypersensitive to ABA. These results suggest that AtTLP9 may participate in the ABA signaling pathway.

Members of this family
  SHOULD possess Tub domain

Domain alignments

This family is also present in:

References

There are 26 gene models in this family



Gene modelDescriptionDomains
LOC_Os01g48370.1 OsFBT1 - F-box and tubby domain containing protein, expressed Tub
LOC_Os01g55430.1 OsFBT2 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os01g55430.2 OsFBT2 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os01g64700.1 OsFBT3 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os01g64700.2 OsFBT3 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os02g08310.1 tubby, putative, expressed Tub
LOC_Os02g47640.1 OsFBT4 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os03g22800.1 OsFBT5 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os03g22800.2 OsFBT5 - F-box and tubby domain containing protein, expressed Tub
LOC_Os03g22800.3 OsFBT5 - F-box and tubby domain containing protein, expressed Tub
LOC_Os04g59130.1 OsFBT6 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os05g36190.1 OsFBT7 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os05g43850.1 OsFBT9 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os05g48670.1 OsFBT10 - F-box and tubby domain containing protein, expressed Tub
LOC_Os07g47110.1 OsFBT11 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os08g01290.1 OsFBT12 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os08g01290.2 OsFBT12 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os08g01290.3 OsFBT12 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os08g01290.4 OsFBT12 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os08g01290.5 OsFBT12 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os08g01290.6 OsFBT12 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os08g01290.7 OsFBT12 - F-box and tubby domain containing protein, expressed Tub
LOC_Os11g06420.1 OsFBT13 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os11g06420.2 OsFBT13 - F-box and tubby domain containing protein, expressed Tub
LOC_Os12g06630.1 OsFBT14 - F-box and tubby domain containing protein, expressed F-box Tub
LOC_Os12g06630.2 OsFBT14 - F-box and tubby domain containing protein, expressed F-box Tub

General references

Boggon, TJ; Shan, WS; Santagata, S; Myers, SC; Shapiro, L. 1999. Implication of tubby proteins as transcription factors by structure-based functional analysis. Science 286(5447):2119-25 PUBMEDID:10591637
Lai, CP; Lee, CL; Chen, PH; Wu, SH; Yang, CC; Shaw, JF. 2004. Molecular analyses of the Arabidopsis TUBBY-like protein gene family. Plant Physiol. 134(4):1586-97 PUBMEDID:15064372
Santagata, S; Boggon, TJ; Baird, CL; Gomez, CA; Zhao, J; Shan, WS; Myszka, DG; Shapiro, L. 2001. G-protein signaling through tubby proteins. Science 292(5524):2041-50 PUBMEDID:11375483