Plant Transcription factor database - Universität Potsdam
version: 3.0

Sorghum bicolor TUB Family


Lai et al. 2004: In mammals, TUBBY-like proteins play an important role in maintenance and function of neuronal cells during postdifferentiation and development. We have identified a TUBBY-like protein gene family with 11 members in Arabidopsis, named AtTLP1-11. Although seven of the AtTLP genes are located on chromosome I, no local tandem repeats or gene clusters are identified. Except for AtTLP4, reverse transcription-PCR analysis indicates that all these genes are expressed in various organs in 6-week-old Arabidopsis. AtTLP1, 2, 3, 6, 7, 9, 10, and 11 are expressed ubiquitously in all the organs tested, but the expression of AtTLP5 and 8 shows dramatic organ specificity. These 11 family members share 30% to 80% amino acid similarities across their conserved C-terminal tubby domains. Unlike the highly diverse N-terminal region of animal TUBBY-like proteins, all AtTLP members except AtTLP8 contain a conserved F-box domain (51-57 residues). The interaction between AtTLP9 and ASK1 (Arabidopsis Skp1-like 1) is confirmed via yeast (Saccharomyces cerevisiae) two-hybrid assays. Abscisic acid (ABA)-insensitive phenotypes are observed for two independent AtTLP9 mutant lines, whereas transgenic plants overexpressing AtTLP9 are hypersensitive to ABA. These results suggest that AtTLP9 may participate in the ABA signaling pathway.

Members of this family
  SHOULD possess Tub domain

Domain alignments

This family is also present in:


There are 13 gene models in this family

Gene modelDescriptionDomains
123770 fgenesh1_pm.C_chr_1000824 F-box Tub
145844 estExt_fgenesh1_pm.C_chr_80192 F-box Tub
4000312 gw1.4.1396.1 Tub
4754085 estExt_Genewise1.C_chr_310103 F-box Tub
4762933 estExt_Genewise1.C_chr_68718 F-box Tub
4768598 estExt_Genewise1.C_chr_97109 F-box Tub
4853493 e_gw1.9.16526.1 F-box Tub
4889811 estExt_Genewise1Plus.C_chr_70055 F-box Tub
5000996 estExt_fgenesh1_pg.C_chr_23955 F-box Tub
5053503 Sb03g030910 Tub
5055722 Sb04g030550 F-box Tub
5056391 Sb05g003900 F-box Tub
5060568 Sb09g021590 F-box Tub

General references

Boggon, TJ; Shan, WS; Santagata, S; Myers, SC; Shapiro, L. 1999. Implication of tubby proteins as transcription factors by structure-based functional analysis. Science 286(5447):2119-25 PUBMEDID:10591637
Lai, CP; Lee, CL; Chen, PH; Wu, SH; Yang, CC; Shaw, JF. 2004. Molecular analyses of the Arabidopsis TUBBY-like protein gene family. Plant Physiol. 134(4):1586-97 PUBMEDID:15064372
Santagata, S; Boggon, TJ; Baird, CL; Gomez, CA; Zhao, J; Shan, WS; Myszka, DG; Shapiro, L. 2001. G-protein signaling through tubby proteins. Science 292(5524):2041-50 PUBMEDID:11375483