Plant Transcription factor database - Universität Potsdam
version: 3.0

Zea mays TUB Family


Lai et al. 2004: In mammals, TUBBY-like proteins play an important role in maintenance and function of neuronal cells during postdifferentiation and development. We have identified a TUBBY-like protein gene family with 11 members in Arabidopsis, named AtTLP1-11. Although seven of the AtTLP genes are located on chromosome I, no local tandem repeats or gene clusters are identified. Except for AtTLP4, reverse transcription-PCR analysis indicates that all these genes are expressed in various organs in 6-week-old Arabidopsis. AtTLP1, 2, 3, 6, 7, 9, 10, and 11 are expressed ubiquitously in all the organs tested, but the expression of AtTLP5 and 8 shows dramatic organ specificity. These 11 family members share 30% to 80% amino acid similarities across their conserved C-terminal tubby domains. Unlike the highly diverse N-terminal region of animal TUBBY-like proteins, all AtTLP members except AtTLP8 contain a conserved F-box domain (51-57 residues). The interaction between AtTLP9 and ASK1 (Arabidopsis Skp1-like 1) is confirmed via yeast (Saccharomyces cerevisiae) two-hybrid assays. Abscisic acid (ABA)-insensitive phenotypes are observed for two independent AtTLP9 mutant lines, whereas transgenic plants overexpressing AtTLP9 are hypersensitive to ABA. These results suggest that AtTLP9 may participate in the ABA signaling pathway.

Members of this family
  SHOULD possess Tub domain

Domain alignments

This family is also present in:


There are 43 gene models in this family

Gene modelDescriptionDomains
GRMZM2G001272_P01 F-box Tub
GRMZM2G001272_P02 F-box Tub
GRMZM2G010117_P01 F-box Tub
GRMZM2G010531_P01 F-box Tub
GRMZM2G010531_P02 F-box Tub
GRMZM2G029649_P01 Tub
GRMZM2G046158_P01 F-box Tub
GRMZM2G046158_P02 F-box Tub
GRMZM2G046816_P01 F-box Tub
GRMZM2G046816_P02 Tub
GRMZM2G046816_P03 F-box Tub
GRMZM2G046816_P04 F-box Tub
GRMZM2G046816_P05 F-box Tub
GRMZM2G049146_P01 Tub
GRMZM2G053311_P01 Tub
GRMZM2G053311_P02 Tub
GRMZM2G062154_P01 Tub
GRMZM2G062154_P02 Tub
GRMZM2G062154_P03 Tub
GRMZM2G068586_P01 F-box Tub
GRMZM2G068586_P02 Tub
GRMZM2G068586_P03 F-box Tub
GRMZM2G081869_P01 Tub
GRMZM2G081869_P02 Tub
GRMZM2G108228_P01 F-box Tub
GRMZM2G108228_P02 Tub
GRMZM2G114736_P01 Tub
GRMZM2G114736_P02 Tub
GRMZM2G114736_P03 Tub
GRMZM2G115701_P01 F-box Tub
GRMZM2G129288_P01 F-box Tub
GRMZM2G129288_P02 F-box Tub
GRMZM2G129288_P03 F-box Tub
GRMZM2G134775_P01 F-box Tub
GRMZM2G136820_P01 Tub
GRMZM2G146519_P01 Tub
GRMZM2G146519_P02 F-box Tub
GRMZM2G146519_P03 F-box Tub
GRMZM2G163726_P01 F-box Tub
GRMZM2G163726_P02 F-box Tub
GRMZM2G163726_P03 Tub
GRMZM2G170739_P01 Tub
GRMZM2G176340_P01 F-box Tub

General references

Boggon, TJ; Shan, WS; Santagata, S; Myers, SC; Shapiro, L. 1999. Implication of tubby proteins as transcription factors by structure-based functional analysis. Science 286(5447):2119-25 PUBMEDID:10591637
Lai, CP; Lee, CL; Chen, PH; Wu, SH; Yang, CC; Shaw, JF. 2004. Molecular analyses of the Arabidopsis TUBBY-like protein gene family. Plant Physiol. 134(4):1586-97 PUBMEDID:15064372
Santagata, S; Boggon, TJ; Baird, CL; Gomez, CA; Zhao, J; Shan, WS; Myszka, DG; Shapiro, L. 2001. G-protein signaling through tubby proteins. Science 292(5524):2041-50 PUBMEDID:11375483