Plant Transcription factor database - Universität Potsdam
version: 3.0

Sorghum bicolor Trihelix Family

Description

Smalle et al. 1998: GT-2 is a plant transcriptional activator that contains two separate, but similar, trihelix DNA-binding domains. GT-1 is similar to GT-2, although it contains only one of such domains. cDNAs that encode GT-2 were isolated from rice (OS-GT2) and Arabidopsis (AT-GT2). Evidence is presented for the existence of an Arabidopsis gene family that is structurally related to AT-GT2. Two members of this GT2-like family, AT-GTL1 and AT-GTL2, have been isolated and characterized. Their sequences suggest that they evolved by a recent gene duplication event. Both AT-GT2 and AT-GTL genes contain an intron in the amino-terminal trihelix motif, indicating that this DNA-binding domain resulted from exon shuffling. RNA gel blot analysis using AT-GTL1 as a probe revealed four transcripts in the aerial part of the plant. All mRNA levels were significantly higher in siliques, suggesting that this gene family may function in fruit and/or seed development. To date, DNA-binding proteins characterized by the trihelix motif have been described only in plants, and may therefore be involved in plant-specific processes. Our results show that in Arabidopsis thaliana, the trihelix motif is not restricted to the GT-1 and GT-2 DNA-binding proteins.

Members of this family
  SHOULD possess trihelix domain

Domain alignments

This family is also present in:

References

There are 21 gene models in this family



Gene modelDescriptionDomains
4784895 e_gw1.1.5223.1 trihelix
4815020 e_gw1.4.1531.1 trihelix
4879562 estExt_Genewise1Plus.C_chr_38114 trihelix
4882371 estExt_Genewise1Plus.C_chr_41275 trihelix Lactamase_B RMMBL
4967368 fgenesh1_pg.C_chr_1003970 trihelix
4980084 fgenesh1_pg.C_chr_4002917 trihelix
4984189 fgenesh1_pg.C_chr_6001076 trihelix
4984494 fgenesh1_pg.C_chr_6001381 trihelix
4997677 estExt_fgenesh1_pg.C_chr_12852 trihelix
4999055 estExt_fgenesh1_pg.C_chr_15126 trihelix
5000395 estExt_fgenesh1_pg.C_chr_22949 trihelix
5008275 estExt_fgenesh1_pg.C_chr_72277 trihelix
5010121 estExt_fgenesh1_pg.C_chr_92247 trihelix
5036550 Sb03g033020 trihelix
5037157 Sb03g044590 trihelix
5037341 Sb04g000520 trihelix
5041713 Sb06g015280 trihelix AA_kinase
5042268 Sb06g023980 trihelix
5042479 Sb06g027540 trihelix
5045809 Sb09g002370 trihelix
5055293 Sb04g023340 trihelix

General references

Nagano, Y. 2000. Several features of the GT-factor trihelix domain resemble those of the Myb DNA-binding domain. Plant Physiol. 124(2):491-4 PUBMEDID:11027698
Nagano, Y; Inaba, T; Furuhashi, H; Sasaki, Y. 2001. Trihelix DNA-binding protein with specificities for two distinct cis-elements: both important for light down-regulated and dark-inducible gene expression in higher plants. J. Biol. Chem. 276(25):22238-43 PUBMEDID:11301338
Smalle, J; Kurepa, J; Haegman, M; Gielen, J; Van Montagu, M; Van Der Straeten, D. 1998. The trihelix DNA-binding motif in higher plants is not restricted to the transcription factors GT-1 and GT-2. Proc. Natl. Acad. Sci. U.S.A. 95(6):3318-22 PUBMEDID:9501260
Zhou, DX. 1999. Regulatory mechanism of plant gene transcription by GT-elements and GT-factors. Trends Plant Sci 4(6):210-214 PUBMEDID:10366876