Plant Transcription factor database - Universität Potsdam
version: 3.0

Carica papaya bHLH Family


Buck & Atchley. 2003: The basic helix-loop-helix (bHLH) family of proteins is a group of functionally diverse transcription factors found in both plants and animals. These proteins evolved early in eukaryotic cells before the split of animals and plants, but appear to function in lsquoplant-specificrsquo or lsquoanimal-specificrsquo processes. In animals bHLH proteins are involved in regulation of a wide variety of essential developmental processes. On the contrary, bHLH proteins have not been extensively studied in plants. Those that have been characterized function in anthocyanin biosynthesis, phytochrome signaling, globulin expression, fruit dehiscence, carpel and epidermal development.

Members of this family
  SHOULD possess HLH domain

Domain alignments

Benchmark against A. thaliana

The Sensitivity and Positive Predictive Value (PPV) were assessed for this family. The data reported by Bailey et al. 2003 for A. thaliana were taken as gold standard.

The gold standard reported 154 members for this family, 122 of which are present in ArabTFDB, giving a PPV of 0.92. Thirty-two additional members not present in ArabTFDB might be false negatives, giving a Sensitivity of 0.80.

This family is also present in:


There are 83 gene models in this family

Gene modelDescriptionDomains
evm.TU.supercontig_1.173 HLH
evm.TU.supercontig_1024.1 HLH
evm.TU.supercontig_106.55 HLH
evm.TU.supercontig_115.69 HLH
evm.TU.supercontig_120.24 HLH
evm.TU.supercontig_1213.3 HLH
evm.TU.supercontig_124.36 HLH
evm.TU.supercontig_129.19 HLH
evm.TU.supercontig_129.36 HLH
evm.TU.supercontig_131.8 HLH
evm.TU.supercontig_141.21 HLH
evm.TU.supercontig_142.14 HLH
evm.TU.supercontig_146.2 HLH
evm.TU.supercontig_157.5 HLH
evm.TU.supercontig_160.31 HLH
evm.TU.supercontig_17.140 HLH
evm.TU.supercontig_177.1 HLH
evm.TU.supercontig_183.33 HLH
evm.TU.supercontig_1892.2 HLH
evm.TU.supercontig_19.155 HLH
evm.TU.supercontig_1938.2 HLH
evm.TU.supercontig_20.65 HLH
evm.TU.supercontig_20.98 HLH
evm.TU.supercontig_200.35 HLH
evm.TU.supercontig_203.4 HLH
evm.TU.supercontig_21.173 HLH
evm.TU.supercontig_21.174 HLH
evm.TU.supercontig_21.8 HLH
evm.TU.supercontig_212.3 HLH
evm.TU.supercontig_239.8 HLH
evm.TU.supercontig_27.34 HLH
evm.TU.supercontig_282.7 HLH
evm.TU.supercontig_289.6 HLH
evm.TU.supercontig_3.229 HLH
evm.TU.supercontig_3.495 HLH
evm.TU.supercontig_3.51 HLH
evm.TU.supercontig_36.187 HLH
evm.TU.supercontig_388.7 HLH
evm.TU.supercontig_4.108 HLH
evm.TU.supercontig_4.168 HLH
evm.TU.supercontig_4.171 HLH
evm.TU.supercontig_44.73 HLH
evm.TU.supercontig_48.15 HLH
evm.TU.supercontig_489.4 HLH
evm.TU.supercontig_489.5 HLH
evm.TU.supercontig_49.31 HLH
evm.TU.supercontig_5.173 HLH
evm.TU.supercontig_5.294 HLH
evm.TU.supercontig_50.36 HLH
evm.TU.supercontig_52.24 HLH
evm.TU.supercontig_52.6 HLH
evm.TU.supercontig_52.92 HLH
evm.TU.supercontig_53.117 HLH
evm.TU.supercontig_537.2 HLH
evm.TU.supercontig_55.141 HLH
evm.TU.supercontig_55.49 HLH
evm.TU.supercontig_55.62 HLH
evm.TU.supercontig_57.82 HLH
evm.TU.supercontig_58.37 HLH
evm.TU.supercontig_59.133 HLH
evm.TU.supercontig_6.128 HLH
evm.TU.supercontig_6.250 HLH
evm.TU.supercontig_61.12 HLH
evm.TU.supercontig_62.156 HLH
evm.TU.supercontig_65.44 HLH
evm.TU.supercontig_65.62 HLH
evm.TU.supercontig_69.28 HLH
evm.TU.supercontig_69.30 HLH
evm.TU.supercontig_69.50 HLH
evm.TU.supercontig_7.50 HLH
evm.TU.supercontig_70.79 HLH
evm.TU.supercontig_71.57 HLH
evm.TU.supercontig_8.191 HLH
evm.TU.supercontig_8.247 HLH
evm.TU.supercontig_8.98 HLH
evm.TU.supercontig_81.11 HLH
evm.TU.supercontig_82.53 HLH
evm.TU.supercontig_84.89 HLH
evm.TU.supercontig_85.116 HLH
evm.TU.supercontig_85.121 HLH
evm.TU.supercontig_92.83 HLH
evm.TU.supercontig_97.75 HLH

General references

Buck, MJ; Atchley, WR. 2003. Phylogenetic analysis of plant basic helix-loop-helix proteins. J. Mol. Evol. 56(6):742-50 PUBMEDID:12911037
Heim, MA; Jakoby, M; Werber, M; Martin, C; Weisshaar, B; Bailey, PC. 2003. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Mol. Biol. Evol. 20(5):735-47 PUBMEDID:12679534
Littlewood, TD; Evan, GI. 1995. Transcription factors 2: helix-loop-helix. Protein Profile 2(6):621-702 PUBMEDID:7553065
Massari, ME; Murre, C. 2000. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20(2):429-40 PUBMEDID:10611221
Quattrocchio, F; Wing, JF; van der Woude, K; Mol, JN; Koes, R. 1998. Analysis of bHLH and MYB domain proteins: species-specific regulatory differences are caused by divergent evolution of target anthocyanin genes. Plant J. 13(4):475-88 PUBMEDID:9680994