Plant Transcription factor database - Universität Potsdam
version: 3.0

Carica papaya mTERF Family

Description

Roberti et al. 2009: The MTERF family is a wide protein family, identified in Metazoa and plants, which consists of 4 subfamilies named MTERF1-4. Proteins belonging to this family are localized in mitochondria and have a modular architecture based on repetitions of a 30 amino acid module, the mTERF motif, containing leucine zipper-like heptads. The MTERF family includes the characterized transcription termination factors human mTERF, sea urchin mtDBP and Drosophila DmTTF. In vitro and in vivo studies show that these factors play different roles which are not restricted to transcription termination, but concern also transcription inititiation and the control of mtDNA replication. The multiplicity of functions could be related to the differences in the gene organization of the mitochondrial genomes. Studies on the function of human and Drosophila MTERF3 factor showed that the protein acts as negative regulator of mitochondrial transcription, possibly in cooperation with other still unknown factors. The complete elucidation of the role of the MTERF family members will allow to unravel the molecular mechanisms of mtDNA transcription and replication.

Members of this family
  SHOULD possess mTERF domain

Domain alignments

This family is also present in:

References

There are 21 gene models in this family



Gene modelDescriptionDomains
evm.TU.supercontig_1.44 mTERF
evm.TU.supercontig_101.29 mTERF
evm.TU.supercontig_13.135 mTERF
evm.TU.supercontig_130.3 mTERF
evm.TU.supercontig_135.44 mTERF
evm.TU.supercontig_139.30 mTERF
evm.TU.supercontig_151.13 mTERF
evm.TU.supercontig_17.157 mTERF
evm.TU.supercontig_171.42 mTERF
evm.TU.supercontig_176.19 mTERF
evm.TU.supercontig_2154.2 mTERF
evm.TU.supercontig_245.11 mTERF
evm.TU.supercontig_287.2 mTERF
evm.TU.supercontig_3.158 mTERF
evm.TU.supercontig_36.116 mTERF
evm.TU.supercontig_36.170 mTERF
evm.TU.supercontig_441.3 mTERF
evm.TU.supercontig_60.8 mTERF
evm.TU.supercontig_62.150 mTERF
evm.TU.supercontig_9.122 mTERF
evm.TU.supercontig_94.72 mTERF

General references

Roberti, M; Polosa, PL; Bruni, F; Manzari, C; Deceglie, S; Gadaleta, MN; Cantatore, P. 2009. The MTERF family proteins: Mitochondrial transcription regulators and beyond. Biochim. Biophys. Acta PUBMEDID:19366610