Plant Transcription factor database - Universität Potsdam
version: 3.0

Physcomitrella patens mTERF Family


Roberti et al. 2009: The MTERF family is a wide protein family, identified in Metazoa and plants, which consists of 4 subfamilies named MTERF1-4. Proteins belonging to this family are localized in mitochondria and have a modular architecture based on repetitions of a 30 amino acid module, the mTERF motif, containing leucine zipper-like heptads. The MTERF family includes the characterized transcription termination factors human mTERF, sea urchin mtDBP and Drosophila DmTTF. In vitro and in vivo studies show that these factors play different roles which are not restricted to transcription termination, but concern also transcription inititiation and the control of mtDNA replication. The multiplicity of functions could be related to the differences in the gene organization of the mitochondrial genomes. Studies on the function of human and Drosophila MTERF3 factor showed that the protein acts as negative regulator of mitochondrial transcription, possibly in cooperation with other still unknown factors. The complete elucidation of the role of the MTERF family members will allow to unravel the molecular mechanisms of mtDNA transcription and replication.

Members of this family
  SHOULD possess mTERF domain

Domain alignments

This family is also present in:


There are 13 gene models in this family

Gene modelDescriptionDomains
120546 e_gw1.33.59.1 mTERF
130222 e_gw1.81.91.1 mTERF
137301 e_gw1.136.138.1 mTERF
144778 e_gw1.219.78.1 mTERF
147348 e_gw1.258.80.1 mTERF
161831 estExt_fgenesh1_pg.C_360115 mTERF
186088 estExt_gwp_gw1.C_890112 mTERF
210658 estExt_Genewise1.C_640072 mTERF
22863 gw1.31.120.1 mTERF
22916 gw1.21.68.1 mTERF
41765 gw1.25.223.1 mTERF
47073 gw1.59.293.1 mTERF
68376 fgenesh1_pg.scaffold_18000122 mTERF

General references

Roberti, M; Polosa, PL; Bruni, F; Manzari, C; Deceglie, S; Gadaleta, MN; Cantatore, P. 2009. The MTERF family proteins: Mitochondrial transcription regulators and beyond. Biochim. Biophys. Acta PUBMEDID:19366610