Plant Transcription factor database - Universität Potsdam
version: 3.0

Sorghum bicolor mTERF Family


Roberti et al. 2009: The MTERF family is a wide protein family, identified in Metazoa and plants, which consists of 4 subfamilies named MTERF1-4. Proteins belonging to this family are localized in mitochondria and have a modular architecture based on repetitions of a 30 amino acid module, the mTERF motif, containing leucine zipper-like heptads. The MTERF family includes the characterized transcription termination factors human mTERF, sea urchin mtDBP and Drosophila DmTTF. In vitro and in vivo studies show that these factors play different roles which are not restricted to transcription termination, but concern also transcription inititiation and the control of mtDNA replication. The multiplicity of functions could be related to the differences in the gene organization of the mitochondrial genomes. Studies on the function of human and Drosophila MTERF3 factor showed that the protein acts as negative regulator of mitochondrial transcription, possibly in cooperation with other still unknown factors. The complete elucidation of the role of the MTERF family members will allow to unravel the molecular mechanisms of mtDNA transcription and replication.

Members of this family
  SHOULD possess mTERF domain

Domain alignments

This family is also present in:


There are 32 gene models in this family

Gene modelDescriptionDomains
141388 estExt_fgenesh1_pm.C_chr_10186 mTERF
149411 estExt_fgenesh1_kg.C_chr_70203 mTERF
149708 estExt_fgenesh1_kg.C_chr_90152 mTERF
150024 estExt_fgenesh1_kg.C_chr_100188 mTERF
4746571 estExt_Genewise1.C_chr_20422 mTERF
4756858 estExt_Genewise1.C_chr_46819 mTERF
4802266 e_gw1.3.14940.1 mTERF
4809266 e_gw1.4.16251.1 mTERF
4810168 e_gw1.4.17448.1 mTERF
4816096 e_gw1.4.16178.1 mTERF
4875517 estExt_Genewise1Plus.C_chr_28958 mTERF
4970595 fgenesh1_pg.C_chr_2001911 mTERF
4979063 fgenesh1_pg.C_chr_4001896 mTERF
4979499 fgenesh1_pg.C_chr_4002332 mTERF
4980133 fgenesh1_pg.C_chr_4002966 mTERF
4996351 estExt_fgenesh1_pg.C_chr_10304 mTERF
4996359 estExt_fgenesh1_pg.C_chr_10317 mTERF
4996360 estExt_fgenesh1_pg.C_chr_10318 mTERF
4997146 estExt_fgenesh1_pg.C_chr_11618 mTERF
5000451 estExt_fgenesh1_pg.C_chr_23057 mTERF
5004460 estExt_fgenesh1_pg.C_chr_42306 mTERF
5008159 estExt_fgenesh1_pg.C_chr_72043 mTERF
5009620 estExt_fgenesh1_pg.C_chr_91343 mTERF
5010486 estExt_fgenesh1_pg.C_chr_100359 mTERF
5027996 Sb01g002030 mTERF
5028029 Sb01g002730 mTERF
5029896 Sb01g034720 mTERF
5037692 Sb04g005820 mTERF
5043575 Sb07g019050 mTERF
5051915 Sb02g037620 mTERF
5054224 Sb03g043300 mTERF
5061535 Sb10g007930 mTERF

General references

Roberti, M; Polosa, PL; Bruni, F; Manzari, C; Deceglie, S; Gadaleta, MN; Cantatore, P. 2009. The MTERF family proteins: Mitochondrial transcription regulators and beyond. Biochim. Biophys. Acta PUBMEDID:19366610