Plant Transcription factor database - Universität Potsdam
version: 3.0

Selaginella moellendorffii mTERF Family

Description

Roberti et al. 2009: The MTERF family is a wide protein family, identified in Metazoa and plants, which consists of 4 subfamilies named MTERF1-4. Proteins belonging to this family are localized in mitochondria and have a modular architecture based on repetitions of a 30 amino acid module, the mTERF motif, containing leucine zipper-like heptads. The MTERF family includes the characterized transcription termination factors human mTERF, sea urchin mtDBP and Drosophila DmTTF. In vitro and in vivo studies show that these factors play different roles which are not restricted to transcription termination, but concern also transcription inititiation and the control of mtDNA replication. The multiplicity of functions could be related to the differences in the gene organization of the mitochondrial genomes. Studies on the function of human and Drosophila MTERF3 factor showed that the protein acts as negative regulator of mitochondrial transcription, possibly in cooperation with other still unknown factors. The complete elucidation of the role of the MTERF family members will allow to unravel the molecular mechanisms of mtDNA transcription and replication.

Members of this family
  SHOULD possess mTERF domain

Domain alignments

This family is also present in:

References

There are 11 gene models in this family



Gene modelDescriptionDomains
103816 e_gw1.28.501.1 mTERF
165772 estExt_Genewise1Plus.C_30035 mTERF
403419 fgenesh2_pg.C_scaffold_1000256 mTERF
408106 fgenesh2_pg.C_scaffold_8000132 mTERF
410501 fgenesh2_pg.C_scaffold_12000401 mTERF
419725 fgenesh2_pg.C_scaffold_43000206 mTERF
444400 estExt_fgenesh2_pg.C_430137 mTERF
74633 e_gw1.0.2510.1 mTERF
77318 e_gw1.1.1705.1 mTERF
83040 e_gw1.5.1206.1 mTERF
92242 e_gw1.13.767.1 mTERF

General references

Roberti, M; Polosa, PL; Bruni, F; Manzari, C; Deceglie, S; Gadaleta, MN; Cantatore, P. 2009. The MTERF family proteins: Mitochondrial transcription regulators and beyond. Biochim. Biophys. Acta PUBMEDID:19366610