Plant Transcription factor database - Universität Potsdam
version: 3.0

Vitis vinifera mTERF Family


Roberti et al. 2009: The MTERF family is a wide protein family, identified in Metazoa and plants, which consists of 4 subfamilies named MTERF1-4. Proteins belonging to this family are localized in mitochondria and have a modular architecture based on repetitions of a 30 amino acid module, the mTERF motif, containing leucine zipper-like heptads. The MTERF family includes the characterized transcription termination factors human mTERF, sea urchin mtDBP and Drosophila DmTTF. In vitro and in vivo studies show that these factors play different roles which are not restricted to transcription termination, but concern also transcription inititiation and the control of mtDNA replication. The multiplicity of functions could be related to the differences in the gene organization of the mitochondrial genomes. Studies on the function of human and Drosophila MTERF3 factor showed that the protein acts as negative regulator of mitochondrial transcription, possibly in cooperation with other still unknown factors. The complete elucidation of the role of the MTERF family members will allow to unravel the molecular mechanisms of mtDNA transcription and replication.

Members of this family
  SHOULD possess mTERF domain

Domain alignments

This family is also present in:


There are 21 gene models in this family

Gene modelDescriptionDomains
GSVIVP00000028001 mTERF
GSVIVP00016568001 mTERF
GSVIVP00019120001 mTERF
GSVIVP00019795001 mTERF
GSVIVP00020547001 mTERF
GSVIVP00021526001 mTERF
GSVIVP00023569001 mTERF
GSVIVP00023571001 mTERF
GSVIVP00023572001 mTERF
GSVIVP00023574001 mTERF
GSVIVP00023645001 mTERF
GSVIVP00025362001 RRM_1 mTERF
GSVIVP00028344001 mTERF
GSVIVP00028545001 mTERF
GSVIVP00029636001 mTERF
GSVIVP00031934001 mTERF
GSVIVP00035689001 mTERF
GSVIVP00036310001 mTERF
GSVIVP00036383001 mTERF
GSVIVP00036397001 mTERF
GSVIVP00037176001 mTERF

General references

Roberti, M; Polosa, PL; Bruni, F; Manzari, C; Deceglie, S; Gadaleta, MN; Cantatore, P. 2009. The MTERF family proteins: Mitochondrial transcription regulators and beyond. Biochim. Biophys. Acta PUBMEDID:19366610